Over a period of almost three centuries, the estate passed along a series of families with names such as Noailhan, Meyrac, Ségur, Salignac, de la Vergne, Escodeca de Boisse etc. From 1575 onwards, the property was owned by five generations of the Essenault family, who ended up renaming it, assigning their name to "Issan" and thus Château d'Issan was born...

In 2012, Françoise and Jacky Lorenzetti, who also own Château Lilian Ladouys in Saint-Estèphe and Château Pédesclaux in Pauillac, joined forces with the Cruse family. With perseverance, passion and courage, different generations have worked to achieve the renewal of Château d'Issan, reaffirming its former glory today.